FAQs

Frequently asked questions about VIBERZI and Irritable Bowel Syndrome with Diarrhea (IBS-D)

IBS-D may be more common than you think. As many as 16 million people in the U.S. suffer from IBS-D.

IBS‑D is not the same as an occasional stomach issue. It is a condition that is long lasting (chronic), that includes frequent episodes of diarrhea as one of the most common symptoms, along with abdominal pain or discomfort.

IBS-D can be a frustrating condition, but there are treatment options. It may seem embarrassing, but being open and honest with your healthcare provider can help you get relief.

Use the Doctor Discussion Guide to help get the conversation started.

It may seem embarrassing, but being open and honest can help you get relief. It’s important to tell your healthcare provider about all your symptoms and how often you are experiencing them. Also, tell your healthcare provider about all the ways you’ve tried to get ahead of abdominal pain and diarrhea.

Use the Doctor Discussion Guide to help get the conversation started.

Talk to your healthcare provider about the right treatment option for you. Pain relievers and antidiarrheal drugs can help treat symptoms in a pinch, but remember to always tell your healthcare provider if you take OTCs more than occasionally. Lifestyle changes such as diet, exercise, stress management, or taking probiotic supplements may also help relieve symptoms. See more IBS-D tips.

Ask your healthcare provider if VIBERZI, a prescription treatment option, may be right for you.

In clinical studies, constipation occurred in 8% of people taking VIBERZI. Severe constipation occurred in less than 1% of people. Stop taking VIBERZI and call your healthcare provider if you have constipation that lasts more than 4 days.

VIBERZI was studied in 2 clinical trials involving more than 2400 men and women, ages 18-80.

It is not known if VIBERZI is safe and effective in children. VIBERZI is a prescription medicine used to treat adults who have IBS-D.

Patients aged 65 years and older were included in the clinical trials. No overall differences in effectiveness were observed between adults aged 65 years and older and younger people. People aged 65 years and older had an increased number of side effects, including serious side effects, compared to people younger than age 65.

Always talk to your healthcare provider about other medicines you might be taking. In clinical studies, people could take Imodium® as needed while also taking VIBERZI. If you are taking VIBERZI, you may take Imodium® occasionally to treat severe diarrhea, but avoid long-term use. Stop taking Imodium® right away if you become constipated.

Imodium® and Pepto Bismol™ are over-the-counter medicines for occasional use. VIBERZI is a prescription medicine that is FDA-approved for daily use in adults with IBS-D to reduce abdominal pain and diarrhea at the same time.

VIBERZI is a federally controlled substance because it may be abused or lead to dependence. But VIBERZI has been designated as a substance that has a low potential for abuse and a low risk of dependence.

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Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Maximum savings limit applies; patient out-of-pocket expense may vary. Please see full Program Terms, Conditions, and Eligibility Criteria at VBZtermsconditions.com.

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VIBERZI

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IMPORTANT RISK INFORMATION
VIBERZI can cause serious side effects, including:

Stop taking VIBERZI right away and get emergency medical care if you have new or worsening stomach-area (abdomen) pain or pain in the upper right side of your stomach-area (abdomen) that may move to your back or shoulder, with or without nausea and vomiting.

Do not take VIBERZI if you:

Before taking VIBERZI, tell your doctor about all of your medical conditions, including if you have liver problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If you are taking VIBERZI you should not take medicines that cause constipation, including Lotronex® (alosetron), anticholinergic medicines, and opioid pain medicines.

Side effects

The most common side effects of VIBERZI include constipation, nausea, and abdominal pain. Stop taking VIBERZI and call your doctor if you have constipation that is severe. These are not all the possible side effects of VIBERZI. Call your doctor for medical advice about side effects.

For further information, please talk to your healthcare professional and see accompanying Patient Medication Guide and full Prescribing Information.

What is VIBERZI?

VIBERZI is a prescription medicine used to treat adults who have Irritable Bowel Syndrome with Diarrhea (IBS-D).

See More
IMPORTANT RISK INFORMATION
VIBERZI can cause serious side effects, including:
  • Inflammation of the pancreas (pancreatitis). Pancreatitis has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
  • A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

Stop taking VIBERZI right away and get emergency medical care if you have new or worsening stomach-area (abdomen) pain or pain in the upper right side of your stomach-area (abdomen) that may move to your back or shoulder, with or without nausea and vomiting.

Do not take VIBERZI if you:
  • Do not have a gallbladder
  • Have or may have had a blockage in your gallbladder or a sphincter of Oddi problem
  • Have or had problems with alcohol abuse, alcohol addiction, or drink more than 3 alcoholic drinks a day
  • Have had pancreatitis or other pancreas problems, including if you have had or may have had a blockage in your pancreas
  • Have severe liver problems
  • Have had long-lasting (chronic) or severe constipation, or problems caused by constipation
  • Have or may have had a bowel blockage (intestinal obstruction)

Before taking VIBERZI, tell your doctor about all of your medical conditions, including if you have liver problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If you are taking VIBERZI you should not take medicines that cause constipation, including Lotronex® (alosetron), anticholinergic medicines, and opioid pain medicines.

Side effects

The most common side effects of VIBERZI include constipation, nausea, and abdominal pain. Stop taking VIBERZI and call your doctor if you have constipation that is severe. These are not all the possible side effects of VIBERZI. Call your doctor for medical advice about side effects.

For further information, please talk to your healthcare professional and see accompanying Patient Medication Guide and full Prescribing Information.

What is VIBERZI?

VIBERZI is a prescription medicine used to treat adults who have Irritable Bowel Syndrome with Diarrhea (IBS-D).