How IBS-D Is Diagnosed? | VIBERZI (eluxadoline) CIV

Help is available

A diagnosis of Irritable Bowel Syndrome with Diarrhea (IBS-D) depends largely on a complete medical history and a physical exam, and often involves a process of ruling out other conditions.

Your primary care provider can determine if you have IBS-D, but he or she may also refer you to a gastroenterologist. A gastroenterologist has dedicated training in the management of diseases of the gastrointestinal tract and liver. Gynecologists and proctologists may also diagnose IBS-D or refer you to a gastroenterologist for further evaluation.

Always consult your healthcare provider for a proper evaluation of your symptoms.

IBS-D is a long-lasting (chronic) condition that includes frequent episodes of diarrhea as one of the most common symptoms, along with abdominal pain.

Be ready: Questions your healthcare provider may ask

Your healthcare provider is likely to ask you a number of questions about your symptoms, lifestyle, and medical history, such as:

When did you first notice your symptoms?
Do your symptoms come and go or stay about the same?
Does anything seem to trigger your symptoms, such as certain foods or stress?
Have you ever been diagnosed with a food allergy or with lactose intolerance?
Have you been diagnosed with any other medical conditions?
What medicines are you taking, including prescription and over-the-counter medicines, vitamins, herbs, and supplements?
Do you have any family history of bowel disorders or colon cancer?

Talk to your healthcare provider to see if VIBERZI is right for you

If you have been diagnosed with IBS-D...

The symptoms of IBS-D can be unpredictable. If you feel frustrated that your symptoms of abdominal pain and diarrhea keep coming back, tell your healthcare provider how IBS-D is affecting you, and ask if VIBERZI is right for you.

If you think you may have IBS-D...

IBS-D is a multisymptom condition. If you have symptoms like abdominal pain and diarrhea, even if they come and go, be sure to make a list of your symptoms and talk to your healthcare provider to see if you have IBS-D.

If you have IBS-D, VIBERZI may be right for you.

Living with IBS-D

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

Stop taking VIBERZI right away and get emergency medical care if you have new or worsening stomach-area (abdomen) pain or pain in the upper right side of your stomach-area (abdomen) that may move to your back or shoulder, with or without nausea and vomiting.

Serious allergic reactions have happened in some people after taking 1 or 2 doses of VIBERZI. Stop taking VIBERZI right away and get emergency medical care if you have signs or symptoms of an allergic reaction, including: swelling of your face, lips, mouth or tongue; shortness of breath or other breathing problems; itching, rash, or hives.
Constipation, including severe constipation that can lead to hospitalization, has happened after taking VIBERZI. Stop taking VIBERZI and call your doctor right away if you develop severe constipation while taking VIBERZI.

Do not take VIBERZI if you:

Do not have a gallbladder
Have or may have had a blockage in your gallbladder or a sphincter of Oddi problem
Have or had problems with alcohol abuse, alcohol addiction, or drink more than 3 alcoholic drinks a day
Have had pancreatitis or other pancreas problems, including if you have had or may have had a blockage in your pancreas
Have had an allergic reaction to VIBERZI
Have severe liver problems
Have had long-lasting (chronic) or severe constipation, or problems caused by constipation
Have or may have had a bowel blockage (intestinal obstruction)

Before taking VIBERZI, tell your doctor about all of your medical conditions, including if you have liver problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If you are taking VIBERZI you should not take medicines that cause constipation, including Lotronex^® (alosetron), anticholinergic medicines, and opioid pain medicines.

The most common side effects of VIBERZI include constipation, nausea, and abdominal pain. Stop taking VIBERZI and call your doctor if you have constipation that is severe. These are not all the possible side effects of VIBERZI. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call
1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

For further information, please talk to your healthcare professional.

US-VBZ-230025

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

IMPORTANT RISK INFORMATION

USE

What is VIBERZI?

VIBERZI^® (eluxadoline) is a prescription medicine used to treat adults who have irritable bowel syndrome with diarrhea (IBS-D).

IMPORTANT RISK INFORMATION

VIBERZI can cause serious side effects, including:

Inflammation of the pancreas (pancreatitis) has happened most often in people who do not have a gallbladder and can lead to hospitalization. Pancreatitis has led to death in some people who do not have a gallbladder. Pancreatitis usually happens within the first week of treatment with VIBERZI, but can happen after 1 to 2 doses of VIBERZI. Your risk of getting pancreatitis is increased if you drink more than 3 alcoholic drinks a day. Limit your use of alcoholic drinks while you are taking VIBERZI.
A spasm in a muscle of the digestive system (called the sphincter of Oddi), which may cause new or worsening abdominal pain. Sphincter of Oddi spasm has happened most often in people who do not have a gallbladder and can lead to hospitalization. This spasm usually happens within the first week of treatment, but can happen after 1 to 2 doses of VIBERZI.

Stop taking VIBERZI right away and get emergency medical care if you have new or worsening stomach-area (abdomen) pain or pain in the upper right side of your stomach-area (abdomen) that may move to your back or shoulder, with or without nausea and vomiting.

Serious allergic reactions have happened in some people after taking 1 or 2 doses of VIBERZI. Stop taking VIBERZI right away and get emergency medical care if you have signs or symptoms of an allergic reaction, including: swelling of your face, lips, mouth or tongue; shortness of breath or other breathing problems; itching, rash, or hives.
Constipation, including severe constipation that can lead to hospitalization, has happened after taking VIBERZI. Stop taking VIBERZI and call your doctor right away if you develop severe constipation while taking VIBERZI.

Do not take VIBERZI if you:

Do not have a gallbladder
Have or may have had a blockage in your gallbladder or a sphincter of Oddi problem
Have or had problems with alcohol abuse, alcohol addiction, or drink more than 3 alcoholic drinks a day
Have had pancreatitis or other pancreas problems, including if you have had or may have had a blockage in your pancreas
Have had an allergic reaction to VIBERZI
Have severe liver problems
Have had long-lasting (chronic) or severe constipation, or problems caused by constipation
Have or may have had a bowel blockage (intestinal obstruction)

Before taking VIBERZI, tell your doctor about all of your medical conditions, including if you have liver problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If you are taking VIBERZI you should not take medicines that cause constipation, including Lotronex^® (alosetron), anticholinergic medicines, and opioid pain medicines.

The most common side effects of VIBERZI include constipation, nausea, and abdominal pain. Stop taking VIBERZI and call your doctor if you have constipation that is severe. These are not all the possible side effects of VIBERZI. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call
1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

For further information, please talk to your healthcare professional.

US-VBZ-230025